Woman who visited A&E seven times and was 3.5 times UK drink-drive limit - was drunk on her own gut bacteria
3 June 2024, 14:33 | Updated: 3 June 2024, 14:44
A woman who visited A&E seven times and was 3.5 times the UK drink-drive limit was drunk on her own gut bacteria.
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The 50-year-old had a rare condition called auto-brewery syndrome which gave her the appearance of being intoxicated.
She presented at hospital with slurred speech and extreme tiredness, only to be discharged with a diagnosis of being drunk - despite saying she had not been drinking.
Blood tests showed her alcohol level was about 285mg per 100ml, around 3.5 times the UK drink-drive limit, the Telegraph reports.
Auto-brewery syndrome sees fungi in the gut create alcohol through fermentation.
Researchers say awareness of this syndrome - which has social, legal, and medical consequences - is essential for proper diagnosis and management.
Over two years the woman visited the emergency department complaining of extreme daytime sleepiness and slurred speech.
She had been on several antibiotic courses for recurrent urinary tract infections alongside a proton pump inhibitor to reduce the amount of acid in her stomach.
Despite not drinking alcohol, she also had elevated blood alcohol levels and alcohol on her breath.
After each hospital visit the woman was discharged with the diagnosis of alcohol intoxication, despite her reports of no alcohol intake, which her family confirmed.
The patient needed up to two weeks off work after each episode and during this time she ate very little.
Her symptoms would get better after one to two weeks, but would return every one to two months.
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On the third visit, the mother was even certificated under the Mental Health Act, as the doctor had concerns for self-neglect when she discharged herself before psychiatric assessment.
However, at her seventh visit the emergency doctor considered a diagnosis of auto-brewery syndrome, and after being prescribed some medication, she was referred to a specialist.
A dietitian suggested a low-carbohydrate diet, and after completing a one month course of an antifungal medication and the diet, the woman's symptoms went away and remained absent for four months.
The woman slowly started to eat carbohydrates again, but one month after doing this she had a recurrence of slurred speech and drowsiness, which led to a fall.
She was advised to restart the low-carbohydrate diet again, and her symptoms resolved.
Writing in the Canadian Medical Association Journal, Dr Rahel Zewude, University of Toronto, and her co-authors, said: "Auto-brewery syndrome carries substantial social, legal, and medical consequences for patients and their loved ones. "Our patient had several (emergency department) visits, was assessed by internists and psychiatrists, and was certified under the Mental Health Act before receiving a diagnosis of auto-brewery syndrome, reinforcing how awareness of this syndrome is essential for clinical diagnosis and management."
