"Our new combination of full-service branches, alongside work cafes, counter-free branches and reduced hours branches, aims to provide the right balance between digital banking and face-to-face money management and guidance."
“Closing a branch is always a very difficult decision and we spend a great deal of time assessing where and when we do this and how to minimise the impact it may have on our customers.
"However, we believe that the introduction of our new Community Bankers and the exciting plans we have for our remaining network of 349 branches and Work Cafes, alongside the rapid and innovative improvements to our award-winning mobile banking app, will provide the right balance of digital banking and human interaction when required."
It comes as part of a growing trend of major banks closing high street branches.
Lloyds Banking Group said in January it would close 61 Lloyds, 61 Halifax and 14 Bank of Scotland branches between May this year and March 2026.
Lloyds blamed the decision to shut the branches on customers shifting away from banking in person to using mobile services.
It said that all workers at the affected branches will be offered jobs elsewhere in the company.
Santander branches set for closure and when they will shut:
Aberdare, Glamorgan, Wales, June 24
Arbroath, Angus, Scotland, June 17
Armagh, County Armagh, Northern Ireland, July 1
Blackwood, Gwent, Wales, June 23
Blyth, Northumberland, August 5
Bognor Regis, West Sussex, July 14
Borehamwood, Hertfordshire, July 1
Brecon, Powys, Wales, June 25
Brixton, London, August 11
Caernarfon, Gwynedd, Wales, July 07
Camborne, Cornwall, July 7
Canvey Island, Essex, August 5
Clacton, Essex, June 16
Cleveleys, Lancashire, June 23
Colne, Lancashire, July 14
Colwyn Bay, Clwyd, Wales, July 24
Crowborough, East Sussex, July 23
Croydon, Surrey, June 16
Cumbernauld, Lanarkshire, Scotland, July 7
Didsbury, Greater Manchester, July 8
Downpatrick, County Down, Northern Ireland, August 6
Dungannon, County Tyrone, Northern Ireland, June 23
Edgware Road, London, August 12
Eltham, London, June 23
Exmouth, Devon, July 15
Falmouth, Cornwall, July 21
Farnham, Surrey, July 29
Felixstowe, Suffolk, July 16
Finchley, London, August 6
Fleet, Hampshire, June 30
Formby, Merseyside, August 11
Gateshead Metro, Tyne & Wear, June 16
Glasgow LDHQ, Lanarkshire, Scotland, June 24
Glasgow MX, Lanarkshire, June 23
Greenford, Greater London, June 24
Hackney, London, July 15
Hawick, Roxburghshire, Scotland, July 24
Herne Bay, Kent, July 8
Hertford, Hertfordshire, July 29
Holloway, London, July 14
Holywell, Clwyd, Wales, Aug 13
Honiton, Devon, July 14
Kidderminster, Worcestershire, June 18
Kilburn, London, June 17
Kirkby, Merseyside, July 22
Launceston, Cornwall, June 16
Louth, Lincolnshire, June 17
Magherafelt, County Londonderry, Northern Ireland, June 24
Malvern, Worcestershire, July 2
Market Harborough, Leicestershire, July 01
Musselburgh, Midlothian, Scotland, June 30
New Milton, Hampshire, July 28
Peterhead, Aberdeenshire, June 26
Plympton, Devon, August 14
Portadown, County Armagh, Northern Ireland, June 30
Pudsey, West Yorkshire, July 28
Rawtenstall, Lancashire, July 15
Ross-On-Wye, Herefordshire, July 30
Ruislip, Greater London, July 7
Rustington, West Sussex, August 5
Saltcoats, Ayrshire, Scotland, July 21
Seaford, East Sussex, July 15
Shaftesbury, Dorset, July 23
Sidcup, Kent, August 11
St Austell, Cornwall, July 8
St Neots, Cambridgeshire, July 30
Stokesley, Cleveland, July 31
Strabane, County Tyrone, Northern Ireland, July 23