Kent coronavirus mutation: What is the E484K strain and will it impact vaccine efficiency?

2 February 2021, 14:36

People queue outside for their coronavirus vaccines.
People queue outside for their coronavirus vaccines. Picture: PA

By Harriet Whitehead

There has been a "worrying development" as a mutation has been detected in the Kent variant of Covid-19.

The mutation, known as E484K, is already present in both South African and Brazilian coronavirus variants.

Laboratory studies have shown that antibodies are less able to bind to a part of the virus known as the spike protein, in order to stop it from unlocking human cells to gain entry.

Will vaccines work against this mutation?

Vaccines currently in use should still work against the mutation, experts have said.

There is, however, concern that this change may reduce vaccine effectiveness. The UK has therefore increased measures to control the spread of new variants, and urgent testing is taking place.

Once vaccination is complete and there are significant levels of immunity across the population, the impact of mutations becomes much more diluted.

It is not uncommon for new variants to appear or change, as viruses mutate to make new copies of themselves to spread and thrive.

Initial results from Moderna suggest that its vaccine is still effective against variants with this mutation, although the body's immune response may not be as strong or prolonged.

Mutations may also make the virus more easy to transmit.

Even in the worst case scenario vaccines can be tweaked to be a better match in a short period of time, say scientists.

Professor Paul Hunter explains: Will Kent mutation evade immunity?

What do the experts think?

Dr Jonathan Stoye, group leader, Retrovirus-Host Interactions Laboratory at The Francis Crick Institute, said: "This suggests that the UK variant is now independently acquiring the E484K change.

"From a virological standpoint, appearance of new variants by mutation during replication cannot be considered surprising.

"Whether this change will provide significant growth advantages for the novel virus causing it to predominate remains to be seen."

Dr Julian Tang, honorary associate professor at the University of Leicester, described the finding as "a worrying development, though not entirely unexpected".

He said it is important that new cases of coronavirus are kept to a minimum to prevent opportunities for the virus to mutate further.

Prof Tang said that allowing spread could provide a "melting pot" for different emerging variants.He said: "We really need to reduce our contact rates to reduce the opportunities for viral spread (and) replication to reduce the speed with which these different virus variants can evolve."

Where is door-to-door testing taking place?

Hancock says testing is now being boosted in Bristol and Liverpool after new variants have been found.

Yesterday 105 cases had been found in the UK as a whole. Today, Hancock said that 11 cases of the variant have been discovered in Bristol, and 32 in Liverpool.

Yesterday, the South African variant of coronavirus has been discovered in eight different areas of England where people had no clear travel links to South Africa.

Door-to-door testing is now being applied in affected areas.

'The South African variant is not a massive cause for concern'

More Latest News

See more More Latest News

Putin issued a chilling threat to the West as he confirmed Russia launched a ballistic missile against Ukraine

'The world must respond': Zelenskyy warns that Putin is 'testing' the West after confirmed use of new ballistic missile

Matt Gaetz withdraws as Donald Trump's nominee for attorney general amid sexual misconduct allegations

Donald Trump nominates Pam Bondi for attorney general hours after Matt Gaetz withdraws

Starmer has backed the International Criminal Court over its arrest warrant for Netanyahu

Netanyahu faces arrest if he travels to Britain as Starmer vows to enforce International Criminal Court warrant

Yvette Cooper has branded the Rwanda scheme a "complete con."

Yvette Cooper to crack down on anti-social behaviour with new 'respect orders' as repeat offenders face jail time

King Charles III And Queen Camilla on Coronation Day

King Charles' coronation cost taxpayer £72 million, report reveals

Pep Guardiola, Manager of Manchester City

Pep Guardiola signs two-year contract extension with Manchester City

Captain Tom's Daughter Hannah Ingram-Moore

Behaviour at Captain Tom charity left ex-boss 'gobsmacked'

Armed robbers attempted to break into the star's Sunderland home.

Masked machete-wielding robbers break into Charlotte Crosby's home while she is upstairs with two-year-old daughter

Police have released new CCTV of Harshita Brella and her husband

Chilling CCTV released of Harshita Brella and prime murder suspect husband on night she was killed

First photos of Gavin and Stacey Christmas Special as James Corden and Ruth Jones mark triumphant finale

First photos of Gavin and Stacey Christmas Special as James Corden and Ruth Jones mark show's triumphant finale

King Charles performs a Hongi, a traditional Maori greeting, with Mere Takoko

King Charles shares traditional Maori nose rub greeting with activist as he launches environmental charity

Putin issued a chilling threat to the West as he confirmed Russia launched a ballistic missile against Ukraine

Putin issues chilling warning to UK and US as he confirms Russia hit Ukraine with new 'experimental' ballistic missile

Telegraph writer Allison Pearson.

Police drop investigation into journalist Allison Pearson over tweet - as review to be launched over handling of case

Exclusive
Angela Rayner has paid tribute to John Prescott

Angela Rayner says John Prescott 'used to call her after PMQs to remind her to stay true to who she is'

Four men have been arrested accused of attempting to rob a mobile phone store

Undercover police arrest four men after EE shop raided by masked gang

Matt Gaetz withdraws as Donald Trump's nominee for attorney general amid sexual misconduct allegations

Matt Gaetz withdraws as Donald Trump's nominee for attorney general amid sexual misconduct allegations